SPEAKER ABSTRACTS

The N protein of human beta coronaviruses (hCoV) is responsible for nucleocapsid assembly and other essential regulatory functions. Its N-terminal domain (N-NTD) interacts and melts the double-stranded transcriptional regulatory sequences (dsTRS), regulating the...

Structural characterization of active substances and their impurities is a common task during Discovery and Development of pesticides and fungicides in the Agrochemical industry. Nuclear magnetic resonance (NMR) spectroscopy and Liquid Chromatography-Mass spectrometry...

The Proteus magnet is a newly developed MR sensor which may be immersed in a fluid to be measured. The Proteus magnet is a dipole magnet fabricated from low cost commercial N52 disc magnets. The magnet is the size of a pocket watch. T1, T2, and D measurements are...

Nuclear magnetic relaxation dispersion (NMRD) is a versatile tool to study nano-scale dynamic processes, at both fundamental and applied levels. Extremely slow molecular motion on ms to mus timescales and such as protein folding, aqueous complexation and surface...

Commercially available and proprietary aluminum adjuvants are a component in over 20 currently U.S.-licensed vaccines. They have been widely used in vaccines for adults and children because of their high safety profile and effectiveness at triggering a greater immune...

Short oligonucleotide therapeutics, including antisense oligonucleotides and siRNAs, are an emerging class of biopharmaceuticals to treat a wide variety of diseases, many of which are inaccessible to small molecule- and protein-based approaches. An increase in FDA...

Background and Rationale: The world-wide diabetes pandemic has heightened the need for early screening and prevention. Type 2 diabetes develops slowly and insidiously, with the earliest stages going undetected. Our laboratory is utilizing compact magnetic resonance...

During development of biological drugs such as monoclonal antibodies (mAbs), it is important to establish comparability of key physicochemical properties, including higher-order structure (HOS), following changes and/or improvements to the manufacturing process. NMR...

Mesoporous materials are widely used in adsorption, separations, drug delivery, gas storage and as catalytic supports, among others. For these and other applications, characterization of their pore structure is needed for full optimization of their surface area...

Glycoconjugates are increasingly used as anti-bacterial vaccines. In their simplest forms, they are similar to glycoproteins. However, even the complete characterization of glycoproteins and glycopeptides continues to present difficulties. While mass spectrometry can...

The open-source Python package, mrsimulator (https://mrsimulator.readthedocs.io), is presented as a simple-to-use, versatile, fast, and open-source library capable of simulating one- and higher-dimensional NMR spectra under static, magic-angle, and variable-angle...

Earth's magnetic field (~50 uT) provides an abundant, cryogen-free magnetic field that can be leveraged for NMR spectroscopy. Without superconducting or bulky permanent magnets, fieldable spectrometers could be developed for applications ranging from benchtop or...

Quantitative NMR (qNMR) is a powerful analytical technology that is capable of quantifying the concentration of any analyte with exquisite accuracy and precision so long as it contains at least one non-labile NMR-active nucleus. Unlike with traditional analytical...

Differences in lipid oxidation products (LOPs) and trace metal concentrations of French fry samples found between two global chain fast-food restaurants in the UK were investigated using high-resolution proton nuclear magnetic resonance (1H NMR) and inductively...

ISO/IEC 17025 is the worldwide quality standard for testing and calibration laboratories. It is the basis for accreditation by an accreditation body. The current version was published in 2018. Implementing ISO/IEC 17025 as part of laboratory quality initiatives offers...

Our group's research combines NMR transport measurements with multi-scale structural and dynamical information to understand the behaviors of soft materials. NMR diffusometry represents a reasonably distinct area of NMR, in parallel with spectroscopy and imaging, and...

Protein therapeutics are a highly successful class of drugs that are currently used to treat a number of serious and life-threatening conditions such as cancer, autoimmune disorders, and infectious diseases including COVID-19. These therapeutics have numerous critical...

Low field nuclear magnetic resonance (NMR) presents a unique opportunity for adaptation into medical and industrial applications. Low field (B0 < 1 T) systems present the advantage of being small and low cost. While low field NMR presents challenges, such as lower...

The NMR community has a long history of homebuilt instrumentation, particularly for applications in solid-state NMR and oriented liquids. The recent proliferation of applications involving biomolecular solids and complex materials have increased the stringency of...

Examples will be presented where NMR-deived 3d-structures of drug candidates assisted drug discovery efforts. In the FVIIa program enhanced potency was achieved by the synthesis of macrocyclic compounds albeit at the emergence of conformational heterogeneity. NMR 3d...

Solid-state NMR spectroscopy can provide unique insight into the composition and properties of pharmaceutical formulations. In particular, both structural and mobility information can be obtained, but the challenge is to relate that information to functional...

Streptococcus pneumoniae (pneumococcus) is a major human pathogen producing more than 100 biochemically unique capsule types, which are the targets of pneumococcal conjugate vaccines (PCVs). Structural elucidation of capsule polysaccharides (PSs) is a prerequisite to...

Nuclear magnetic resonance (NMR) spectroscopy is a keystone analytical technique in any industrial laboratory. NMR is a universal detector and finds wide application in diverse materials and fields. However, the analytical power of NMR is often tempered by relatively...

Silicone elastomers have industrial relevance as adhesives, sealants, and engineered parts in a myriad of commercial applications. Commercial silicones can be subject to a variety of curing conditions and harsh aging conditions, such as complex strain fields, that...

USP general chapters Nuclear Magnetic Resonance Spectroscopy and Applications of Nuclear Magnetic Resonance Spectroscopy are currently being revised by the quantitative nuclear magnetic resonance (qNMR) Expert Panel. Since the last revision in 2013, there has been a...

While the primary degradants of cannabidiol and related cannabinoids have been well documented since the 1960s, the mechanistic pathways to them are complex and multitudinous. An indepth analysis of the metastable intermediates of many of the key degradation routes...

Solid-state NMR (ssNMR) has been increasingly recognized as a high resolution spectroscopic tool to characterize pharmaceutical materials. [Trends in Analytical Chemistry, 135, 116152, 2021] However, ssNMR application in pharmaceutical sciences is often limited by the...

Blood serum metabolites reflect the physiological state of the body and allow measurement of changes occurring during disease or an infection. Metabolomics can be used to capture these changes and provide more accurate ways of diagnosing diseases, providing prognostic...

Solid-state nuclear magnetic resonance (NMR) spectroscopy provides powerful information about local atomic structure in solids. 13C is by far the most frequently utilized nucleus for the analysis of pharmaceuticals. Other NMR-active nuclei in organic compounds and...

Protein or peptide molecules fold into higher order structure (HOS) . Altered HOS could affect therapeutic efficacy and safety, therefore it needs to be characterized. In the process of biosimilar development and regulatory review, the HOS similarity should be...