SPEAKERS

Nashville, Tennessee

Fábio Almeida

Fábio Almeida

Federal University of Rio de Janeiro

Exploring the druggability of the N-terminal domain of the nucleocapsid protein (N-NTD) of human coronaviruses

Technical Session #1: “Sweets and Meats: Polysaccharide and Protein Targets in Vaccine and Inhibitor Development”

1994 – Graduation in Biochemistry at University of São Paulo

1994-1996- Postdoctoral Research Associate at University of Pennsylvania – Protein NMR – Structure of membrane proteins

1997 – now – Professor at the Federal University of Rio de Janeiro

Carlos Amezcua

Carlos Amezcua

FMC Corporation

Application of a Hybrid LC-SPE System to Impurity Isolation: A Practical Tool for Structural Characterization by NMR Spectroscopy and Mass Spectrometry

Technical Session #7: “Sweating the small stuff – tales of impurities and degradants”

BS in Chemistry from Universidad de las Americas. Ph.D. in Organic Chemistry from Texas Christian University. Postdoc at UT Southwestern Medical Center. Carlos worked at Baxter Healthcare for several years and currently works for FMC Corporation.

Bruce Balcom

Bruce Balcom

University of New Brunswick

A Portable Submersible MR sensor – The Proteus Magnet

Technical Session #9: “Fields of Dreams, a new era of instrumentation”
materials”
Canada Research in Material Science MRI. UNB MRI Centre has developed and commercialized numerous practical materials MR/MRI methods. We have developed a family of low field portable magnets, employed by select labs worldwide.

Sven Bodenstedt

Sven Bodenstedt

ICFO - The Institute of Photonic Sciences

Applications of ultralow-field-cycling NMR

Technical Session #4: “Relaxation, it’s not just for weekends anymore”

From 2019: PhD fellow at the Institut of Photonic Sciences in Barcelona, Spain

2015: Master’s degree in physics at the University of Stuttgart, Germany

2012: Bachelor’s degree in physics at the University of Stuttgart, Germany

Katharine Briggs

Katharine Briggs

University of Maryland, School of Pharmacy

Time Domain wNMR for the Characterization and Quality Assurance of Vaccines and Adjuvants

Technical Session #5: “A magnet a day keeps the doctor away: how MR is helping the healthcare industry”

Dr. Katharine Briggs is a research associate at the University of Maryland School of Pharmacy in the lab of Dr. Bruce Yu where she is exploring ways in which benchtop wNMR methods could be useful in the pharmaceutical industry.

Robert Brinson

Robert Brinson

National Institute of Standards and Technology

NMR Fingerprinting Strategies for Short Oligonucleotide Therapeutics

Technical Session #3: “Bring Me a Higher (Order) Structure”

Robert applies NMR measurements to define the critical quality attribute of higher order structure for biologics, with a focus on monoclonal antibody therapeutics and short oligonucleotides.

David P. Cistola

David P. Cistola

Texas Tech University Health Sciences Center El Paso

Plasma Water T2 Measures the Impact of Lifestyle Modification on Cardiometabolic Health: The PREMIER Clinical Trial

Technical Session #5: “A magnet a day keeps the doctor away: how MR is helping the healthcare industry”

David P. Cistola, M.D., Ph.D. is a professor and biomedical scientist at Texas Tech University Health Sciences Center El Paso. His research applies compact magnetic resonance technology to develop practical screening tests for diabetes prevention.

Igor Dikiy

Igor Dikiy

Regeneron Pharmaceuticals

Applications of NMR and statistical methods in establishing analytical comparability and process consistency for mAbs

Technical Session #3: “Bring Me a Higher (Order) Structure”

Igor Dikiy is in the Protein Biochemistry group at Regeneron, using NMR spectroscopy to establish HOS comparability for mAbs. Igor was a postdoc at the CUNY ASRC with Dr Kevin Gardner and got his PhD from the Weill Cornell GSMS with Dr David Eliezer.

Henry Enninful

Henry Enninful

Leipzig University

Advanced NMR Cryoporometry Characterization of Mesoporous Solids

Technical Session #6: “Check out for the versility of NMR to investigate materials”

Henry R. N. B. Enninful obtained his BSc. and MSc. degrees in engineering from the Kwame Nkrumah University of Science and Technology (KNUST), Ghana and the Politecnico di Torino (PoliTo), Italy. He is currently a Ph.D. student and research assistant at the Felix Bloch Institute for Solid State Physics at the Leipzig University, Germany, where he investigates pore space architecture mainly by nuclear magnetic resonance. In particular, he is interested in understanding and characterizing the complexity of disordered nanoporous solids with NMR cryoporometry.

Darón Freedberg

Darón Freedberg

CBER/FDA

Glycoprotein and glycopeptide analysis using practical NMR methods

Technical Session #1: “Sweets and Meats: Polysaccharide and Protein Targets in Vaccine and Inhibitor Development”

Darón Freedberg received his bachelor’s degree in 1990 from UCSD in Chemistry, where he studied stereodynamics with Jay Siegel. In 1994, he earned his Ph.D. at UCLA where he studied conformational isotope effects and helium encapsulated in Buckeyballs, under Frank Anet. After a postdoctoral fellowship studying protein structure and dynamics at the NIH with Dennis Torchia, he took a position at the FDA. Since 1997, he has been combining his experience in stereochemistry, conformational analysis, structure and dynamics. He is now a Principal Scientist who reviews pharmaceutical polysaccharide-based vaccines and leads a research team in NMR studies of oligo- and polysaccharide structure-function relationships.

Philip Grandinetti

Philip Grandinetti

Ohio State University

mrsimulator: A cross-platform object-oriented open-source software package for fast solid-state NMR spectral simulation and analysis

Technical Session #6: “Check out for the versility of NMR to investigate materials”

Philip Grandinetti received his B.S in chemistry in 1982 and M.S. in physical chemistry in 1984 at West Virginia University while working on electron paramagnetic resonance studies of phase transitions in ferro- and anti-ferroelectric materials under Professor Nar S. Dalal. He moved on to the University of Illinois, Urbana-Champaign for a Ph.D. in physical chemistry under Professor Jiri Jonas; developing and applying in-situ high pressure nuclear magnetic resonance (NMR) methodologies in the study of dynamics of model elastohydrodynamic lubricants as well as pressure-induced phase transitions in lipids. After finishing his Ph.D. he took a post-doctoral position at the University of California, Berkeley in the lab of Professor Alex Pines from 1989 to 1993. He began his career at Ohio State University as a professor in chemistry in 1993. During his career he made contributions to a new class of solid-state NMR methods for obtaining high-resolution and sensitivity of half-integer quadrupolar nuclei. His research continues to focus on the development and application of multi-dimensional solid-state NMR methods for structural studies of non-crystalline materials and heterogeneous materials.

Derrick Kaseman

Derrick Kaseman

Los Alamos National Laboratory

Developments in Earth’s Magnetic Field NMR for Industrial Applications

Technical Session #9: “Fields of Dreams, a new era of instrumentation”
materials”

Derrick Kaseman is a Scientist in the Bioenergy and Biome Sciences Group at Los Alamos National Laboratory. His interests include using NMR to elucidate the structures of materials from small organic molecules to inorganic glasses.

Gennady Khirich

Gennady Khirich

Genentech

Analysis of Systematic and Random Uncertainty in Quantitative NMR Measurements Using a Monte Carlo Method

Technical Session #10: “Smarter Faster Better: Computation and Optimization in Drug Discovery and Characterization”

Gennady Khirich received his Ph.D. in biophysical chemistry from Yale University. Currently, he is a Technical Development Scientist specializing in NMR spectroscopy within the Small Molecule Process Impurities Group at Genentech.

Adam Le Gresley

Adam Le Gresley

Kingston University

“Real-World” Evaluation of Lipid Oxidation Products and Trace Metals in French Fries From Two Chain Fast-Food Restaurants

Technical Session #7: “Sweating the small stuff – tales of impurities and degradants”

PhD at the University of Surrey under Prof Kuhnert. NIH PDRA at Drexel College of Medicine, Philadelphia, US. Kingston University in 2009, Research group working on fluorogenic compounds for pathogen detection and NMR for complex mixture analysis.

Louis Madsen

Louis Madsen

Virginia Tech

Tracking motions in materials by NMR diffusometry: Challenges, discoveries, and dangers

Technical Session #2: “NMR Developments for materials science and polymers applications”

NMR of polymers, liquid crystals, ionic liquids, electrolytes, and other soft materials. PhD Caltech with Dan Weitekamp, Postdoc UNC with Ed Samulski and Victoria U with Paul Callaghan. Virginia Tech Professor since 2006.

Michael Maiwald

Michael Maiwald

BAM

Laboratory accreditation as a reliable indicator of technical competence for testing, calibration and measurement organizations – An introduction to ISO/IEC 17025 using the example of qNMR spectroscopy

ValidNMR Session #3: “Laboratory accreditation as a reliable indicator of technical competence for testing, calibration and measurement organizations – An introduction to ISO/IEC 17025 using the example of qNMR spectroscopy.”

Dr. Michael Maiwald is physico-chemist. He graduated from Ruhr-University
Bochum, Germany, in 1994. In 2012 his habilitation (post-doctoral lecturing
qualification) followed at Technical University Kaiserslautern, Germany.

Since 2008 he is head of the division Process Analytical Technology at
Bundesanstalt für Materialforschung und -prüfung (BAM) in Berlin, Germany
Previously, he was research associate and group leader at central services
analytics at Merck KGaA, Darmstadt, Germany.

His research activities are in the field of quantitative online NMR spectroscopy,
other analytical online methods, chemometrics, gas analysis, and sensor
automation concepts.

He works actively in different industrial, scientific, and standardization working
groups.

John Marino

John Marino

NIST-IBBR

Principal component analysis (PCA) classification of 1D and 2D NMR spectra from Protein Therapeutics: a tool for automated and objective decision making

Technical Session #10: “Smarter Faster Better: Computation and Optimization in Drug Discovery and Characterization”

Since 2008, Dr. Marino has served as the leader of the NIST Biomolecular Structure & Function Group and Associate Director of the Institute for Bioscience and Biotechnology Research (IBBR), a joint research institute of the University of Maryland and NIST, in Rockville, Maryland. Dr. Marino joined NIST in 1997 as a Research Chemist and was appointed Adjunct Professor at the University of Maryland. Prior to coming to NIST, Dr. Marino completed a Ph.D. in Chemistry from Yale University in 1995 and an A.B in Chemistry from Princeton University in 1989. After his PhD, he held an Alexander von Humboldt post-doctoral fellowship for two years at the Goethe Universität in Frankfurt, Germany. Dr. Marino’s research focuses on precision measurement of biomolecular structure and dynamics, with a recent focus on NMR techniques for characterization of the higher-order-structure (HOS) of biotherapeutics.

Michele Martin

Michele Martin

National Institute of Standards and Technology

Quantitative Relaxation Measurements for Low Field Magnetic Resonance

Technical Session #4: “Relaxation, it’s not just for weekends anymore”

Michele received a PhD in physical chemistry from UC Davis. Her work focused on using single-sided NMR to detect tomato paste spoilage. She is now in NIST’s Magnetic Imaging Group, working on low field NMR/MRI for industrial and medical applications

Rachel Martin

Rachel Martin

University of California, Irvine

Easy and reproducible construction of NMR transceiver coils using 3D printing

Technical Session #9: “Fields of Dreams, a new era of instrumentation”
materials”

Rachel Martin is a Professor of Chemistry and Molecular Biology & Biochemistry at University of California, Irvine. Her research group works on NMR instrumentation and methods development as well as biological applications. Website: probemonkey.com

Klas Meyer

Klas Meyer

BAM

ValidNMR Session #2 (Open Forum — Sli.do assisted): “What does ‘Quality’ mean to you?”

ValidNMR Session #6 (Open Forum — Sli.do assisted): “Open Q+A / Ask us anything”

Klas received his Ph.D. in Analytical Chemistry from Humboldt Universität zu Berlin in 2017 for the work
on “High-pressure NMR spectroscopy” in gas mixtures and process applications. The experimental work
was performed in the Process Analytical Technology group of Michael Maiwald at Bundesanstalt für
Materialforschung und -prüfung (BAM). After that he joined Magritek GmbH in Aachen as Application
Scientist for Benchtop NMR spectrometers. Since end of 2018 he returned to BAM responsible for the
research fields of quantitative NMR spectroscopy (qNMR) and process spectroscopy. Since 2020 he took
over the chair position of the ValidNMR group together with the co-chair John Edwards.

Luciano Mueller

Luciano Mueller

Bristol-Myers Squibb

Utility of Solution-State NMR Structures in Drug Discovery

Technical Session #10: “Smarter Faster Better: Computation and Optimization in Drug Discovery and Characterization”

Ph. D: Natural Sciences ETH Zurich 1978 Post doctoral: Varian Associates 1978 Postdoctoral UC Berkeley, 1979 NMR Facility manager, Caltech 1980-1983 Staff scientist, Smith Kline Beckman, 1983-1989 Bristol-Myers Squibb, 1989 – present.

Eric Munson

Eric Munson

Purdue University

Practical Applications of Solid-State NMR Analysis of Pharmaceuticals

Technical Session #8: “Ready, Pharma, ONE….!”

Dr. Eric Munson is the Dane O. Kildsig Chair and Head of the Department of Industrial and Physical Pharmacy at Purdue University. His research program focuses on the characterization of pharmaceutical solids, with an emphasis on SSNMR spectroscopy.

Moon Nahm

Moon Nahm

University of Alabama at Birmingham

NMR is essential in our fight against pneumococci

Session #1: “Sweets and Meats: Polysaccharide and Protein Targets in Vaccine and Inhibitor Development”

I have been studying bacterial infections for 30+ years. My research has been focused on the bacterial polysaccharide capsules. Our studies also led us to find accurate ways to measure immune responses to pneumococcal vaccines

Benjamin Reiner

Benjamin Reiner

Dow Chemical

Non-Fourier NMR Techniques Optimized for Polymeric Materials

Technical Session #2: “NMR Developments for materials science and polymers applications”

Ben’s background is in organometallic synthesis and catalysis. He joined the NMR department at Dow Chemical in 2020. His research focuses on structural and reaction characterization of functional polymeric materials using non-Fourier NMR techniques.

April Sawvel

April Sawvel

Lawrence Livermore National Laboratory

Magnetic Resonance Imaging as a Non-Destructive Method for the Characterization of Silicone Elastomer Chemistry In-Situ

Technical Session #6: “Check out for the versility of NMR to investigate materials”

April Sawvel is a staff scientist at Lawrence Livermore National Laboratory specializing in the development of magnetic resonance methods to determine aging and degradation mechanisms of silicone elastomers.

Dan Sorensen

Dan Sorensen

Health Canada

Setting standards: Revision of USP general chapters <761>/<1761>.

ValidNMR Session #1 (Keynote Lecture): “Setting Standards: Revision of USP general chapters <761>/<1761>”

Dr. Sorensen is a GMP Inspector at Health Canada and volunteers on a USP Expert Panel (qNMR) as an individual expert—not a Government Liaison. His expressed opinions are personal and do not represent the legal positions or guidance of Health Canada.

Throughout his career as a pharmaceutical scientist, he focused on the applications of NMR for discovery, development and commercialization of natural products, antibiotics, anticancer drugs and other medicines. While working at McMaster University as an NMR Application Specialist and GMP Quality Manager, he facilitated the creation of a GMP-compliant NMR contract testing laboratory. He regards science as a profession that requires tacit knowledge to be shared through coaching, mentoring, workshops and communities of practice (e.g., ValidNMR).

Hannah Stone

Hannah Stone

GW Pharmaceuticals

Mechanistic studies in the oxidative and photodegradation of cannabinoids by insitu NMR analysis

Technical Session #7: “Sweating the small stuff – tales of impurities and degradants”

Hannah Stone is a Senior R&D Scientist at GW Pharmaceuticals in the UK. She has worked at GW for 4 years on a variety of synthetic and characterisation projects. She graduated with a Masters in Chemistry from Durham University in 2017.

Yongchao Su

Yongchao Su

Merck & Co, Inc.

19F Solid-state NMR Analysis of Pharmaceutical Materials

Technical Session #8: “Ready, Pharma, ONE….!”

Dr. Su is a Principal Scientist in Analytical R&D at Merck. He has contributed over 100 peer-reviewed papers on ssNMR studies of pharmaceutical, biophysical and material characterizations, and published patents on biological and chemical therapeutics.

Ljubica Tasic

Ljubica Tasic

UNICAMP - University of Campinas

Elucidating blood serum signatures of COVID-19 patients in Brazil using 1H-NMR

Technical Session #5: “A magnet a day keeps the doctor away: how MR is helping the healthcare industry”

As Associate Professor at the University of Campinas, Ljubica leads a research group in Biological Chemistry whose interests are understanding the modified metabolic pathways in diseases, diseases molecular basis, and the use of NMR.

Amrit Venkatesh

Amrit Venkatesh

École Polytechnique Fédérale de Lausanne

Sensitivity-enhanced 14N, 17O and 35Cl solid-state NMR for structure determination of organic compounds and pharmaceuticals at natural abundance

Technical Session #8: “Ready, Pharma, ONE….!”

MSc chemistry – Sri Sathya Sai Institute of Higher Learning, India. 2013 PhD in physical chemistry – Prof. Aaron Rossini group, Iowa State University, USA. 2020 Marie Curie Postdoctoral fellow – Prof. Lyndon Emsley group, EPFL, Switzerland. 2021

Deyun Wang

Deyun Wang

FDA

NMR Based Similarity Metrics for Higher Order Structure Assessment among U.S. Marketed Insulin Therapeutics

Technical Session #3: “Bring Me a Higher (Order) Structure”

Dr. Deyun Wang is from the FDA’s Northeast Medical Products Laboratory (NMPL). He obtained his Doctorate in Bioorganic Chemistry from New York University. He is currently charged with overseeing the NMR operations for NMPL.

Jeffery White

Jeffery White

Oklahoma State University

Multinuclear, Multidimensional, and Multi-field NMR Reveals Complex Active Sites in Zeolite Catalysts

Technical Session #2: “NMR Developments for materials science and polymers applications”

Dr. Jeffery L. White is the Professor and B.P. Chair, School of Chemical Engineering, Oklahoma State University. Previously, Dr. White served as an Assistant and tenured Associate Professor at North Carolina State University.

Dennis Woertge

Dennis Woertge

Procter and Gamble Service GmbH

Quantitative single sided NMR MOUSE T1 relaxometry using MPM

Technical Session #4: “Relaxation, it’s not just for weekends anymore”

External student at the TU Ilmenau, Germany Department of technical physics II/ polymer physics Master of science in Biophysics, Goethe University Frankfurt Germany