Speakers and Bios
Rockville, MD, United States
Luke is a NIST research chemist working on the development, validation and application of advanced multidimensional NMR methods for the structural characterization of protein therapeutics including monoclonal antibodies.
University of Georgia
Athens, GA, United States
The Structural Role of N-Glycosylation in interactions between Antibodies and Receptors
Adam Barb, an associate professor at the University of Georgia. Dr. Barb earned B.S. and M.S. degrees in plant science before pursuing a Ph.D. at Duke University under Christian Raetz and Pei Zhou in the Department of Biochemistry. There, Dr. Barb combined in vitro enzyme kinetics measurements of an essential deacetylase in Gram-negative bacteria with solution NMR spectroscopy to probe the structure/function relationship of this important antibiotic target. He subsequently moved to the Complex Carbohydrate Research Center at the University of Georgia to work under James Prestegard and began studies on antibody glycosylation. Dr. Barb joined the Roy J. Carver Department of Biochemistry, Biophysics & Molecular Biology at Iowa State University in 2012 and was awarded the ASBMB Herb Tabor Award for studies on the structural role of antibody glycosylation in receptor interactions. The Barb Lab moved to the Department of Biochemistry and Molecular Biology at the University of Georgia in 2019.
Pacific Northwest National Laboratory
Richland, WA, United States
Dr. Tim Bays joined PNNL in 2005 and is currently a researcher in the Applied Chemistry Team of the Chemical & Biological Processing Group. He conducts research in the area of renewable and fossil hydrocarbon fuels in support of the Department of Energy?s Vehicle Technologies Office and Bioenergy Technologies Office under the Co-Optimization of Fuels & Engines Program. Dr. Bays holds a Ph.D. in inorganic chemistry from the University of Idaho and a B.S. in chemistry from the U.S. Naval Academy. Prior to arriving at PNNL, he was an associate professor at the U.S. Military Academy at West Point, New York. Prior to his career in chemistry, Dr. Bays served on active duty with the U.S. Navy from 1987-1992, and has since served as a drilling Navy Reservist, attaining the rank of Commander, retiring in 2013. During 2009-2010, Dr. Bays was mobilized by the Navy to Baghdad, Iraq, where he served as a liaison between the U.S. Embassy, the Commanding General and the Government of Iraq. Dr. Bays is a veteran of Operation Desert Storm and Operation Iraqi Freedom. He is the recipient of the Defense Meritorious Service Medal and a Department of State Meritorious Honor Award (2010) for service at the U.S. Embassy in Baghdad, Iraq, and co-recipient of a 2012 R&D 100 Award.
University of Liverpool
Liverpool, United Kingdom
After a PhD in Chemistry at the University of Lyon and the Centre for High Field NMR completed in 2008, Frédéric Blanc moved to the State University of New York as a Lavoisier Fellow and then the University of Cambridge as a Marie Curie Fellow. He was appointed to a Lectureship (US equivalent to Assistant Professor) in the Department of Chemistry at the University of Liverpool in December 2012 and promoted to Reader (US equivalent to Professor) in October 2018. His research program is focused on applying solid-state NMR spectroscopy to tackle a wide range of challenges across materials chemistry. In particular, he has recently been interested in capturing transient catalytic intermediates in heterogeneous catalysis; probing charge carrier mobilities in energy materials; and investigating host guest interactions in supramolecular assemblies. He has also been interested in exploiting the large sensitivity gain of solid state dynamic nuclear polarization to probe insensitive nuclei (for example, oxygen-17 at natural abundance or low-gamma nuclei). He serves as Co-Director of the 800 MHz Facility in Liverpool and is on Royal Society NMR discussion group committee. He coordinates the newly established Connect NMR UK network, promoting engagement with a large range of potential NMR users. Further details can be found in the group website at and Twitter at @DrFredericBlanc
Karlsruhe Institute of Technology
Carlo Botha is a PhD candidate at Karlsruhe Institute of Technology (KIT) in the working group of Prof. Dr. Manfred Wilhelm. Where his focus is on method development, with respect to the hyphenation of chromatography to a medium resolution benctop NMR spectrometer.
Merck and Co., Inc.
Kenilworth, NJ, United States
What can NMR analysis reveal about Acyl Glucuronides and their relative stability to inform on potential DILI risk?
Dr. Alexei Buevich holds a Ph.D. and a Master's Degrees in Physical Organic Chemistry (NMR) from the Lomonosov Moscow State University, Russia. Prior to joining the Schering-Plough NMR Structural Chemistry group in 2001 he was a Senior Research Scientist at the Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences (1990-1994), a Post-Doctoral Fellow in BioNMR at Umea University, Sweden (1995-1997), and then a Research Associate at Rutgers University, NJ (1997-2001). He is currently a Principal Scientist at Merck in the NMR Structure Elucidation group, and his research interests include development and application of new experimental and computational methods for R&D problems in the pharmaceutical industry.
US Drug Enforcement Administration
Dulles, VA, United States
Low Field qNMR of Methamphetamine HCl
Charlotte Corbett has worked as a forensic drug chemist for 17 years. She has specialized in nuclear magnetic resonance (NMR) for the past seven years. The U.S. Drug Enforcement Administration utilizes NMR for purity determination, structure differentiation, identification, and structure elucidation. DEA continues to simplify quantitation through automation.
Green Imaging Technologies
Fredericton, NB, Canada
Mike received his bachelor and masters degrees from the University of New Brunswick. Following this he received his PhD from the University of Waterloo. After graduation, Mike was a post-doctoral fellow at NASA?s Jet Propulsion Lab. Following this position, Mike worked for six years as a research scientist with Bubble Technology Industries (BTI) in Chalk River Ontario Canada. Mike joined Green Imaging Technologies in 2015 as a principal research. With GIT, Mike focuses on expanding the suite of measurements for core analysis via NMR.
Birmingham, West Midlands, United Kingdom
NMR Cryoporometry - Characterization of Porous Materials Using Liquid NMR
Robert Evans is Senior Lecturer of Physical Chemistry at Aston University. He holds a MChem and PhD from the University of Oxford. He moved to Aston following postdoctoral work at Ecole Polytechnique, with Stefano Caldarelli, and the University of Manchester, first with Gareth Morris and Mathias Nilsson and then in the group of Nicola Tirelli. His research interests involve the use of Nuclear Magnetic Resonance in the analysis of polymers, soft materials and complex mixtures.
Albuquerque, NM, United States
Hilary Fabich is a scientist at ABQMR Inc. She has been working with magnetic resonance (MR) for over ten years and, in addition to her current home at ABQMR, has worked with groups in Montana, Sweden, England and New Zealand. Her expertise is in imaging complex systems such as bubble formation in a model scale fluidized bed and, more recently, in using MR to study chemical reactions at process conditions of high temperature and high pressure. She has also studied fluid dynamics in supercritical flows and has been part of a project to build an MRI system to image plant roots in the field. She enjoys exploring unique applications of MR that require one of a kind hardware.
Maplewood, MN, United States
I have worked with 3M Corporate Research Analytical Laboratory specializing in NMR, competitive analysis, and complex problem solving for 19 years.
Istituto di Ricerche Chimiche e Biochimiche G Ronzoni
Automated 2D quantitative NMR spectroscopy for complex drug analysis
I have amassed over 25 years of experience at the forefront of characterisation and structural studies of oligosaccharides, especially heparin and heparin derivatives, using NMR. Consequently, our laboratory is the primary point of reference for researchers and industrial concerns working in heparin field in the world. I?m the vice-director of the Institute, contributing to the coordination and the management of the scientific activities. I have also responsibility for running the NMR Centre at the Ronzoni Institute in Milan, including management of the staff organisation. Research highlights have included elucidation of the structural basis of the specificity of influenza viruses H1N1, in wild type and mutated forms, revealing hitherto unknown features, the identification of a contaminant of heparin production, uncovering details of interactions between heparin and important proteins including antithrombin and fibroblasts growth factors (FGF1 and 2). I have managed research projects, from a range of European and American funding sources My twenty-five years? experience in analysis and characterization of heparin and other glycosaminoglycans is proved by more than 100 peer reviewed articles published in primary journals. The main scientific activity at the Ronzoni Institute was devoted to the elucidation of relationships between structure, biological activity and applied properties of oligo- and polysaccharides. My group has given especially important contributions to the advancement of knowledge and to the development of new applications in the field of heparin and other glycosaminoglycans. Some of major contributions (mostly in collaboration with international groups) have been: i) implementation of a new NMR method to determine the mono- and disaccharide composition of heparin and low molecular weight heparins; ii) structural characterization of low-molecular weight heparins and heparin oligosaccharides; iii) determination of the conformation of heparin oligomers and assessment of their 3D structures in complexes with AT and growth factors, through molecular modelling and NMR spectroscopic studies. In 2008, together FDA and MIT, I?ve contributed to the identification of the heparin contaminant, and to the development of control methods to ensure heparin quality. Within this activity, in collaboration with Prof A.E. Yates of the University of Liverpool and Dr T.R. Rudd of NIBSC of London we developed new analytical tools to guarantee the safety of heparin drugs coupling NMR and chemometric techniques. The main object of the study was the creation of a library of heparin NMR spectra, both monodimensional (proton) and bidimensional (1H-13C heteronuclear correlation HSQC), constituted by accepted bona fides samples, according to the current criteria of the manufacturer, and representing the natural structural variability of heparin. More recently, in collaboration with Bruker Biospin, we developed tools in AssureNMR software for qualitative assessment, porcine verses bovine heparin, and quantitative analysis of heparins and impurities.
Jian Zhi Hu
Pacific Northwest National Laboratory
Richland, WA, United States
I received my Ph.D. degree in 1994 from a joint training program between the Chinese Academy of Sciences, Wuhan Institute of Physics and the Department of Chemistry, University of Utah, USA. Currently, I am a senior staff scientist, graduate and postdoctoral researcher advisor, in Pacific Northwest National laboratory located in Richland, Washington State. I have extensive research experience in solid-state NMR spectroscopy with more than 200 peer-reviewed publications, h-index of 42, about 6000 web of science citations, two R&D 100 awards, and 11 US Patents.
Singapore University of Technology and Design
Shaoying HUANG received the B.Eng., M. Eng., and Ph.D. degree from Nanyang Technological University, Singapore in 2003, 2006, and 2011, respectively. She joined the University of Hong Kong in 2010 working on computational electromagnetics (EM), and Massachusetts Institute of Technology in 2012 working on magnetic resonance imaging (MRI) related EM problems, both as a postdoctoral fellow. She has joined Singapore University of Technology and Design (SUTD) as an assistant professor in the pillar of Engineering Product Development since 2014. She is an adjunct assistant professor in the department of surgery in National University of Singapore, Singapore. Her main research interests include, low-field MRI, non-linear MRI image reconstructions, and RF aspects of MRI. Moreover, she is also interested in wireless power transfer, wideband RF/microwave components, radiofrequency (RF)/microwave noninvasive/contactless sensing.
South San Francisco, CA, United States
Joe Lubach is a Senior Scientist in the Small Molecule Pharmaceutical Sciences department at Genentech, Inc., where he has been since 2007. In his current role, he leads the Solid-State Chemistry group within the Pharmaceutics department, working on physical form screening and solid-state characterization of small molecule drug substances and drug products. His personal research interests center around expanding applications of solid-state NMR spectroscopy across the pharmaceutical discovery and development landscape, and he has authored or co-authored forty peer-reviewed publications and three reference chapters stemming from his work. Joe holds a Ph.D. in Pharmaceutical Chemistry from the University of Kansas (2007), where he worked with Prof. Eric Munson.
University of Canterbury
Christchurch, Canterbury, New Zealand
Yevgen (Eugene) Matviychuk is a post-doctoral fellow at the Department of Chemical and Process Engineering at the University of Canterbury in Christchurch, New Zealand. With the group of Dr. Daniel J. Holland, he focuses on developing novel statistical methods for improving quantification in NMR spectroscopy, including experiments on medium field benchtop instruments and reaction monitoring. Eugene obtained his PhD in Electrical Engineering from the University of Colorado Boulder in 2016 and his B.Sc. degree from the Donetsk National Technical University, Ukraine in 2007. His research interests include modern signal processing and machine learning, specifically with applications to high-dimensional data analysis.
Korimako Chemical Limited
Wellington, WLG, New Zealand
Evan started working in magnetic resonance as a post-doctoral researcher at UC Santa Barbara developing fundamental dynamic nuclear polarization NMR hardware and methods. These key developments were the basis for more refined applications in medical imaging and studying the interactions of water with macromolecules. As senior applications engineer at Magritek Ltd, he developed the NMR Rock Core Analyzer. This was followed by implementing standard and advanced time-domain NMR methods for service laboratories and research institutions. He then transitioned to benchtop spectroscopy developing industrial applications for the Magritek Spinsolve with an emphasis on automation and quantitative NMR (qNMR) methods intended for industrial applications in pharmaceutical, neutraceutical, forensics, and petroleum. At Korimako Chemical Limited Evan continues to develop practical benchtop NMR methods with academic and industrial partners focusing on commercially viable solutions. He continues to draw on previous experiences from a diverse experience in NMR, choosing the promising methods from relaxation, diffusion, spectroscopy, or combinations to apply to new problems.
University of Alberta
Edmonton, AB, Canada
Assistant Professor at the University of Alberta; Postdoctoral Fellow at the Francis Bitter Magnetic Laboratory, MIT with R. Griffin studying dynamic nuclear polarization NMR. Studied quadrupolar nuclei with S. Kroeker (University of Manitoba) in crystalline and amorphous materials during his PhD studies.
BASF Advanced Materials and Systems Research
Ludwigshafen, RLP, Germany
Aqueous polymer dispersions are widely used base products for many industrial products such as coatings and adhesives. From the chemical engineering point of view, they are especially attractive because they allow low-viscosity formulations with cross-linked polymers. Furthermore, the use of polymer dispersions instead of dissolved polymers allows to eliminate or greatly reduce the amount of organic solvents needed in these products. From a material characterization point of view, polymer dispersions with technically relevant solids contents are rather challenging due to their high turbidity, possible instabilities under shear forces and various changes upon dilution. One of the few noninvasive spectroscopic options to study such dispersions in their native state is time domain (TD) NMR. In the presentation, we provide a survey of information on the state of the polymer available from such measurements and how it can be correlated with micromechanics and application properties of films and composites obtained after drying of the polymer dispersions. Furthermore, the potential of unilateral NMR for film formation studies is shortly discussed.
Kansas Analytical Services, LLC
Wellington, CO, United States
Opportunities and Challenges in 19F Detection of Fluorinated Pharmaceuticals
Matt Nethercott joined Kansas Analytical Services, LLC in 2014 as a senior analyst after completing a postdoctoral position in the laboratory of Dr. Eric Munson from 2012 ? 2014 at the University of Kentucky. In his current role, he is responsible for acquiring, analyzing, and reporting to clients the solid-state NMR data for submitted samples. Matt obtained a Ph.D. in Chemistry from Michigan State University (2012), under the advisement of Dr. David Weliky. The work there focused on applying 2D 13C/13C solid-state NMR spectroscopy to obtain structural information on the HIV gp41 protein?s fusion peptide region.
College Park, MD, United States
Clark Ridge is a researcher at the US FDA in the area of food and additive safety. He has been an analytical NMR spectroscopist there for eight years and in that time has worked on a great variety of food and food related projects including in part, food dyes, chemical contaminants, adulterated products, seafood toxins, and dietary supplements.
Kingston, United Kingdom
Cameron Robertson is a PhD researcher funded by GSK. Currently doing the bulk of his research on complex mixture characterization and quantitation using novel high resolution and semi-automated methods. These techniques are being implemented on a vary busy and active NMR instrument which has led to the publication of two papers this year and more to come. Cameron Robertson is excited to show what he can do with these novel NMR and software solutions to make the academic and commercial researchers life more efficient and effective.
KU Leuven - cMACS
Born in Athens in 1974, he studied Chemistry at the University of Athens and graduated from the École Normale Supérieure de Lyon (ENS). His Master's degree was obtained from the Institute of Nuclear Physics of Lyon on particle and nuclear Physics. He earned his PhD on Solid-State NMR in the Solid-State NMR Group of the ENS under the direction of Prof. L. Emsley. He was a post-doctoral fellow in the Lawrence Berkeley National Laboratory (Materials Sciences Division) and University of California Berkeley, invited by Prof. A. Pines, where he developed methods and instruments for high-resolution magnetic resonance in the presence of inhomogeneous and rotating magnetic fields.
In 2004 he joined the Laboratory of Structure and Dynamics using Magnetic Resonance (LSDRM) of the French Atomic Energy Commission (CEA in Saclay), as a tenured staff principal investigator. In 2008 he was awarded a Starting ERC grant for the project R-EvolutioN-M-R.
In 2017 he joined the Faculty of Bioscience Engineering of the Katholic University of Leuven, as a Professor in Nuclear Magnetic Resonance. His research is performed at the Department of Microbial and Molecular Systems, in the Center for Membrane Separations, Adsorption, Catalysis and Spectroscopy for Sustainable Solutions (cMACS).
His current projects include: 1) New methods and instruments for improving magnetic resonance detection of ultra-small samples, 2) Portable sensors for industrial applications of magnetic resonance, 3) Hyphenated MR instrumentation, 4) Low-field magnetic resonance in metabolism and porous materials, 5) solid-state magnetic resonance spectroscopy and imaging.
St. Louis, MO, United States
Molecular Basis of Secondary Relaxation in Stiff-Chain Glassy Polymers
Jacob Schaefer received his BS in chemistry from Carnegie Institute of Technology (Pittsburgh) in 1960, and his PhD in physical chemistry from the University of Minnesota (Minneapolis) in 1964. He joined Monsanto Company (St. Louis) as a research scientist in 1964 and worked on the determination of the microstructure of copolymers using solution-state 1H NMR. In 1969 he published the first 13C NMR spectra of synthetic copolymers, and in 1972, the first magic-angle spinning 13C NMR spectrum of a solid polymer. He joined the faculty of Washington University in 1986 as the Charles Allen Thomas Professor of Chemistry. His research specialty there has been high-resolution solid-state NMR. He is the co-inventor of cross-polarization magic-angle spinning (CPMAS, 1976) and rotational-echo double resonance (REDOR, 1989). Both techniques have become standard methods and are currently in use world wide. The Schaefer research program is making contributions to previously unsolved problems in biology and polymer science by performing solid-state NMR measurements on relevant, and often large and heterogeneous, materials that are not suited to diffraction or solution-state NMR measurements. He is the author of over 300 publications.
Wiesbaden, Hesse, Germany
Torsten Schoenberger is MSc in Analytical Chemistry. He is head of the NMR unit of the Forensic Science Institute, Federal Criminal Police Office (Bundeskriminalamt, BKA), Germany. His latest research fields are covering the quantitative NMR spectroscopy. In addition to quantification of all kinds of organic substances, one of his current main tasks is the structure elucidation of new psychoactive substances. This current work also covers the counterfeit detection of pharmaceuticals as well as the analysis of explosives and polymer based technical products.
ExxonMobil Research & Engineering
Annandale, NJ, United States
Debbie has a BS degree from The College of New Jersey and a MS from Lehigh University. She currently works in the Analytical Sciences Laboratory at ExxonMobil Research & Engineering Co. in Clinton NJ. Her primary job role and expertise is in NMR spectroscopy. Debbie has 25+ years experience in applying NMR techniques to a variety of petrochemical applications.
University of Maryland, Baltimore
Rockville, MD, United States
Marc Taraban received a MS in physical chemistry from Novosibirsk State University and a PhD in chemical physics from the Russian Academy of Sciences, Institute of Chemical Kinetics & Combustion with specialization in spin chemistry. His research in the Laboratory of Magnetic Phenomena used methods of Chemically Induced Dynamic Nuclear Polarization (CIDNP) to observe intermediate species in fast radical reactions and magnetic field effects on enzymatic reactions. As a visiting assistant professor at the University of Utah, Taraban continued his research on mechanisms of enzymatic processes using spin chemistry techniques and expanded his focus to structural determination of biomacromolecules and polymers using Small Angle X-Ray Scattering (SAXS). At the University of Maryland, College Park, he worked in the biomaterials area to create force-sensitive nano-networks (FSNNs) from soft and wet viscoelastic materials assembled from peptides and other biopolymers in order to construct injectable and biodegradable mechanosensors and drug release matrices to aid the repair and rehabilitation of damaged musculoskeletal tissues. More generally, he is interested in applications of modern biophysical and structural biology methods (e.g., Dynamic Light Scattering, Microflow Imaging, SAXS and Small-Angle Neutron Scattering) to study the structural characteristics and conformational dynamics in biopolymers, molecular assemblies, and dendrimers. His current research investigates the water transverse relaxation rate as a probe for noninvasive characterization of biopharmaceuticals. To this end, he uses low field benchtop time-domain NMR instruments including under flow conditions.
Elwin van der Cruijsen
Enzyme kinetics determined by rapid real-time NMR
Within the DSM Biotechnology Center, I am using NMR to bring insight into projects that relates to enzyme and strain development.
Karlsruhe, Ba-Wü, Germany
Manfred Wilhelm is a full professor for Polymeric Materials at the Institute for Chemical Technology and Polymer Chemistry KIT since 2006. He studied Chemistry in Mainz and Toronto. Afterwards, he did his Ph.D. in solid state NMR with Prof. H. Spiess (MPI, Mainz). During this time, he spent one year at the University of California, Santa Barbara, USA, in the group of Prof. B.F. Chmelka. After the PhD he did a postdoc at the Weizmann -Institute in Israel. He then returned to the Max- Planck Institute for Polymers in Mainz. In 2001, he finished his habilitation, and in 2004 became Associate Professor at TU Darmstadt. He received a number of prizes including the Reimund Stadler Prize (2001) and the nomination of the Neo Award in 2012. His scientific ideas have reached the general public trough different media. In 2016 he was offered a chair at the Bayreuth University and 2017 a directorship at the IPF in Dresden. His main research interests are non-linear rheology, structure-property relationships for polymeric materials and the development of new combination of simultaneous characterization methods. Examples for his work are the development of the Fourier transformation rheology as a new evaluation method for non-linear rheology or the combination of rheology with dielectric spectroscopy, medium field NMR or Small-angle X-ray scattering.